With the games coming thick and fast now across multiple competitions, Gameweek 6 of the 2025/26 Premier League season arrives this weekend with some mouth-watering encounters that could alter the league table decisively.
The big games this weekend involve Liverpool travelling to Selhurst Park, Chelsea facing the Seagulls at home, and the Gunners travelling away to St. James’ Park to face Newcastle United.
So, let’s take a look at all the fixtures from Gameweek 6 of the 2025/26 Premier League season.
Last time out in the league, while Man United beat Chelsea at home, Brentford lost to Fulham. The Bees are a difficult side at home, and with no games in midweek both squads are properly rested.
United have a lot of players coming back, with Matheus Cunha, Mason Mount, and Diogo Dalot all available for this game. Brentford also do not have many injury concerns, with Dango Ouattara also marking a return from injury.
Brentford’s topsy-turvy form will be a worry for coach Keith Andrews, as their defence has looked shaky. The Red Devils, meanwhile, looked good in attack against Chelsea.
This could be another loss for the Bees, as a resurgent United have the firepower up front to trouble them with the likes of Cunha and Bryan Mbeumo. That said, Brentford are no pushovers and could at least breach United’s defence.
Score prediction: Brentford 1–2 Man United
While Chelsea came back from 1–0 down against League One side Lincoln City to win 2–1, Brighton delivered a 6–0 annihilation of Barnsley — also of the third tier — with their Paraguayan midfielder Diego Gómez bagging a hattrick.
The Blues have a few injury problems coming into this game, with Cole Palmer and Liam Delap out and Benoît Badiashile and Roméo Lavia doubtful. As for the Seagulls, they’ll be missing Maxim De Cuyper, Adam Webster, and Jack Hinshelwood.
Last season, Brighton won both their league games against Chelsea, though their start to this season hasn’t been encouraging. This is a tough one to call, as both teams have defensive weaknesses that can be exploited, but both sides also have great options in attack. This could end an entertaining draw.
Score prediction: Chelsea 2–2 Brighton
Having been knocked out of the League Cup in the previous round, both teams are well rested coming into this game. Last weekend, Leeds secured an away win against a struggling Wolves, while Bournemouth were held to a goalless draw by Newcastle.
Both teams have minor injury concerns, with Lucas Perri ruled out for Leeds and Daniel James and Wilfried Gnonto doubtful. Bournemouth, on the other hand, will be without Enes Ünal and Adam Smith.
Leeds only have one win in their last four league games, while Bournemouth have been unbeaten in their last four with two wins; they’re the better team on paper in terms of squad quality and form.
Though Leeds at home are a tough proposition and have been defensively solid barring the game against Arsenal, the Cherries have enough firepower to grab all three points in this encounter.
Score prediction: Leeds United 1–2 Bournemouth
The Cityzens have turned around their form after losses against Spurs and Brighton and are looking dangerous again, which is bad news for the visiting Clarets this weekend.
After the draw against Arsenal last weekend, City travelled to Huddersfield Town in midweek for the League Cup with a heavily rotated side and won comfortably. Burnley, meanwhile, have had a reality check after returning to the Premier League and are second from bottom in the table after five games with just one win. They were also knocked out of the EFL Cup by Cardiff City in midweek — another poor result that will affect their confidence ahead of the big game at the Etihad.
City do have a host of injury concerns coming into this fixture, with Omar Marmoush, Rayan Aït-Nouri, and Mateo Kovacic all ruled out with injuries and Rayan Cherki, Erling Haaland, and Abdukodir Khusanov doubtful. Burnley, on the other hand, also have some players missing, with Connor Roberts, Zeki Amdouni, Jacob Brunn Larsen, and Jordan Beyer all unavailable to start against the Cityzens.
Burnley manager Scott Parker could deploy the same tactic he used against Liverpool (which almost earned him a point) — playing five at the back and look to frustrate City by relinquishing most of the possession. City, meanwhile, will look to score big; playing a low block against them usually isn’t a great idea as they thrive on more possession. Considering the gulf in quality between the two sides, this should be an easy win for Pep Guardiola & Co.
Score prediction: Man City 2–0 Burnley
Having won their respective League Cup fixtures earlier in the week, Crystal Palace and Liverpool will face each other in the next round. The Reds fielded a heavily rotated side and still came out 2–1 winners against Southampton, while the Eagles beat West Ham 2–1.
Coming into this league fixture, both teams have injury issues. Yeremy Pino injured for Palace, though Ismaïla Sarr could return. As for Liverpool, they were given extremely bad news after the Southampton game, with their young centre-back Giovanni Leoni likely out for the season with an ACL injury. In-form forward Hugo Ekitike is suspended for this game.
Selhurst Park hasn’t been a happy hunting ground for Liverpool, though they did manage to win here last season. They haven’t been tight in defence this season, but they have shown their attacking prowess and have won every game in the league so far. Palace, in contrast, do not have a 100% record, but they are also unbeaten in the league this season.
In terms of squad quality on paper, Liverpool have a clear edge over Palace and are our favourites for all three points here, though this will be a difficult game for them, as Palace are no pushovers and did clinch the Community Shield by beating them on penalties last month.
Score prediction: Crystal Palace 1–2 Liverpool
Nottingham Forest will look to return to winning ways after a horrendous start to the season, while Sunderland have been the surprise package and have performed above expectations thus far.
While Forest had to suffice with a draw in their Europa League opener against Real Betis in midweek, Sunderland fought hard to earn a point against Aston Villa in the league last weekend after going down to ten men in the first half.
Except for the win in their opening game, Forest haven’t won in their last six games across all competitions. The Black Cats, meanwhile, have lost just once thus far in the league.
Coming into this game, both teams have players missing due to injury, with Ola Aina and Murillo out for the Tricky Trees and Habib Diarra injured in the Sunderland camp, with defender Reinildo Mandava suspended.
This is a difficult one to call. Even though Forest have shown signs of improvement over the last few games, they do not look solid at the back the way they did last season. However, attack-wise they haven’t done too badly. Sunderland could pose issues for the Forest defence, but Ange Postecoglou’s men have enough firepower up front to hurt them. This could be a feisty draw.
Score prediction: Nottingham Forest 2–2 Sunderland
The Lilywhites won their recent League Cup encounter 3–0 against Doncaster Rovers, while Wolves beat Everton 2–0 in the League Cup, which must have given them a massive boost of confidence. In the league last weekend, Spurs came back from 2–0 down against Brighton to earn a point, showing great powers of recovery. Wolves, meanwhile, were humbled by Leeds United at home.
Spurs are struggling significantly with injuries, with Dominic Solanke, Randal Kolo Muani, Dejan Kulusevski, and James Maddison being the major absentees, while Wolves only have André and Enso González out for this game.
Looking at the form of these two sides, Spurs have been unbeaten in their last four games, while Wolves are languishing at the bottom of the league table with five losses out of five and looking like early relegation contenders.
Having added some much-needed depth to their attacking ranks this summer and proving defensively solid, Spurs look great under new boss Thomas Frank. They should be able to inflict a defeat on Wolves easily in this encounter.
Score prediction: Spurs 2–0 Wolves
Both these teams have started the season poorly, though Fulham have been affected by poor refereeing decisions, while Villa’s results are mostly down to their poor performances.
However, both teams won their latest midweek games, with Fulham beating Cambridge United in the EFL Cup and Villa winning their opening Europa League game against Serie A outfit Bologna.
As far as injuries are concerned, the Villans have Amadou Onana and Youri Tielemans out injured, while the Cottagers will be without the services of Antonee Robinson and Kevin.
Fulham are on a three-game winning streak, while their recent Europa League game marked Villa’s first win of this season. Unai Emery’s men have largely looked blunt in attack, and the loss of form in the case of both Ollie Watkins and Morgan Rogers is a massive concern.
Beating Bologna would have given them the massive confidence they have needed to get their campaign well and truly going, though Fulham aren’t easy opponents; they possess a potent attack that can trouble any team in the league. We expect this to be another entertaining draw.
Score prediction: Aston Villa 1–1 Fulham
Both Newcastle and Arsenal have lost one league game so far this season and have been looking defensively resolute. Last time out, while the Magpies won their League Cup game against Bradford City by a handsome scoreline of 4–1, the Gunners too had a comfortable outing as they beat Port Vale 2–0.
Newcastle have major injury concerns, with Fabian Schär and new signings Yoane Wissa and Jacob Ramsey out injured, while Arsenal will be missing Martin Ødegaard, Piero Hincapié, and Noni Madueke, alongside long-term absentees Gabriel Jesus and Kai Havertz.
St James’ Park is one of the most hostile grounds for visiting teams in the league, and Arsenal didn’t have a great outing last time they played here. However, with Bukayo Saka back in the fold and Gabriel Martinelli looking ominous in attack, last season’s runners-up have a strong front line that can really trouble the Newcastle defence. Moreover, Arsenal’s defence is near-impregnable and could make things difficult for the hosts’ attackers.
Based on form and squad depth, Arsenal are our favourites for all three points in this one, though expect it to be a very tight affair.
Score prediction: Newcastle 1–2 Arsenal
Everton lost in the Merseyside derby last weekend and were then beaten by Wolves in the League Cup; they’ve not won in their last three games. The Hammers, on the other hand, have won one game in their last three and lost to Crystal Palace last weekend.
The Toffees don’t have any major injury concerns coming into this game, barring defender Jarrad Branthwaite, who is out for a long while. West Ham, meanwhile, have Tomáš Soucek and Aaron Wan-Bissaka as the major absentees for this encounter.
Everton have started life at their new home ground well, so this could be another difficult game for West Ham, though they do have an in-form and consistent Jarrod Bowen up front, who will try his best to outshine Everton’s latest hero, Jack Grealish.
Here’s another difficult game to call, and we consider a draw to be the likeliest outcome. Everton did show defensive frailties against Wolves, which West Ham must have taken note of. Even though West Ham have defensive issues of their own, they can definitely hurt Everton in attack.
Score prediction: Everton 1–1 West Ham
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